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  1. General Info
  2. Effects Info
  3. Reference
Drug Details
01. General Information
Name Aurora kinase inhibitor
Drug Type Small molecule
Toxicity Organism Test Type Route(Dose)
Structure 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 297
Ref_1
Pair Name Tanshinone IIA, Aurora kinase inhibitor
Partner Name Tanshinone IIA
Disease Info [ICD-11: 2B66.0] Oral squamous cell carcinoma Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation Down-regulation Phosphorylation H3C1 hsa8350
Down-regulation Phosphorylation AURKB hsa9212
In Vitro Model SCC-9 Tongue squamous cell carcinoma Homo sapiens (Human) CVCL_1685
SCC-15 Tongue squamous cell carcinoma Homo sapiens (Human) CVCL_1681
SCC-25 Tongue squamous cell carcinoma Homo sapiens (Human) CVCL_1682
CAL-27 Tongue adenosquamous carcinoma Homo sapiens (Human) CVCL_1107
In Vivo Model The OSCC xenograft models were constructed by s.c. injection of CAL27 (2×10⁶) or SCC25 (3×10⁶) cells into the right flank of 6-week-old athymic nude mice (n = 5).
Result Targeting Aurora B kinase with Tanshinone IIA suppresses tumor growth and overcomes radioresistance
03. Reference
No. Title Href
1 Targeting Aurora B kinase with Tanshinone IIA suppresses tumor growth and overcomes radioresistance. Cell Death Dis. 2021 Feb 4;12(2):152. doi: 10.1038/s41419-021-03434-z. Click
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